Liraglutide

Liraglutide is highly effective because it acts as a GLP-1 receptor agonist, mimicking the natural hormone that regulates appetite and blood sugar. It promotes weight loss by reducing hunger and slowing gastric emptying, while treating type 2 diabetes by stimulating insulin release and lowering glucagon levels only when blood sugar is high. 

Key Reasons for Effectiveness:

• Appetite Regulation & Weight Loss: Liraglutide binds to appetite receptors in the brain, increasing feelings of fullness and reducing hunger, which leads to lower calorie intake.
• Glucose-Dependent Insulin Release: It stimulates the pancreas to release insulin only when blood sugar levels are elevated, minimizing the risk of hypoglycemia.
• Reduced Glucagon Secretion: It suppresses the release of glucagon, a hormone that causes the liver to produce more glucose.
• Delayed Gastric Emptying: It slows down the rate at which food leaves the stomach, which prevents sharp spikes in blood sugar after meals.
• Metabolic Stability: Unlike natural GLP-1, which breaks down in minutes, liraglutide is designed to last for roughly 13 hours, making it highly effective for daily, once-daily, consistent glycemic control. 

Liraglutide is used to manage type 2 diabetes (under the brand name Victoza® for Type 2 Diabetes) and for chronic weight management (under the brand name Saxenda). Studies have shown that it can lead to significant weight loss, with some users losing roughly 8% of their body weight in one year.