Cagrisema Pen 12mg-2.6ml Pen

CagriSema – A Dual‑Incretin, Once‑Weekly Solution for Sustainable Weight Management

CagriSema represents a next‑generation approach to obesity treatment by pairing two complementary hormones—semaglutide, a GLP‑1 receptor agonist, and cagrilintide, an amylin‑mimetic analogue—into a single, once‑weekly multidose pen. Each dose delivers a fixed 6 mg of semaglutide plus 6 mg of cagrilintide, administered via a 240‑click pen that can be used for an entire month without the need for refills. The dual‑incretin strategy harnesses the synergistic actions of the two pathways: semaglutide amplifies glucose‑dependent insulin secretion, slows gastric emptying, and profoundly reduces hunger, while cagrilintide adds a potent satiety signal through the amylin‑receptor system, curbing post‑prandial food intake and promoting energy expenditure. Together, they provide a “two‑pronged” appetite‑control effect that is stronger than either agent alone.

Clinically, CagriSema is designed to drive meaningful fat loss while preserving lean body mass—a critical goal for patients seeking durable weight reduction without compromising muscle health. Early phase‑3 data suggest that the combined therapy produces greater reductions in body‑weight percentage and improves metabolic markers (HbA1c, lipid profile, blood pressure) compared with monotherapy, likely because the enhanced satiety translates into lower caloric intake and the amylin‑mediated mechanisms support lipolysis. The weekly dosing schedule improves adherence, and the multidose pen eliminates the inconvenience of daily injections.

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